Chapter 130 Thoughts (Additional Update) (Ch 816404963)

He Youwei did not go back, but asked for a long vacation from Union Hospital and temporarily lived in a small detached villa of Hailufeng Company.
Taking into account his busy work and the fact that it is not easy for men and women to be alone together, Jiang Miao arranged for Shu Ya to take care of He Youwei.
Shuya is currently studying the chicken mushroom. Thanks to the brain-boosting food therapy and the genetic rules taught to her by Jiang Miao, she has made rapid progress in the research of the chicken mushroom.
She has studied the underlying mechanism of the symbiosis between Alternaria album and termites. By imitating this symbiotic mechanism, Alternaria album can be cultivated in a targeted manner. The growth cycle is about 75 days, and the yield per mu can reach 3,000 to 4,000 kilograms.
At this time, Shuya finally understood where Jiang Miao’s ability to quickly develop various technologies came from. She thought that Jiang Miao had mastered the laws of genetics, which gave him this ability.
Considering the acceptance of the outside world, Shuya did not immediately announce the relevant technology and papers on Alpinia terrestris, and still claimed to the outside world that he was researching morels.
Jiang Miao also discussed He Youwei’s situation with Shuya. Although they could not teach her all the genetic laws, 11 of them were relatively simple and did not involve brain strengthening or life extension, so they could still be taught to her.
Inside the edible fungi laboratory.
He Youwei, who was already wearing protective clothing and a helmet, looked at the pig gene sequence on the computer screen.
Shuya treated the teaching task as a holiday: “Based on the rules of growth functional genes, you should determine which gene fragments may affect its growth.”
He Youwei subconsciously wanted to raise her glasses, and then she reacted when she touched the plastic mask in front of her. She looked at the pig’s genetic sequence carefully, then picked up a small notebook and continued to record the relevant information, while also performing calculations and deductions.
He Youwei, who did not have a photographic memory, was much slower in her research than Shuya. Also, she was not familiar with genetic laws, so her calculations were clumsy.
More than three hours later.
She deduced 17 growth-related gene fragments, of which 6 gene fragments formed a group, another 5 genes formed another group, and the remaining 6 gene fragments have not yet found corresponding genomes.
After lunch, she hurried to the laboratory again.
Using specific nutrients and drugs, they tried to stimulate the function of these genomes in pig stem cells grown in a petri dish.
The drugs and nutrients she uses are common and can pass through the cell membrane, directly reach the chromosomes and act on the gene sequence; or they can produce indirect compounds that act on the gene sequence.
An afternoon passed by unknowingly.
He Youwei’s eyes became brighter and brighter.
Shuya took a look at the genome she had selected: “Gene fragment 3 of this genome will increase the growth rate of bones under the action of trace amounts of calcium and vitamin K. Do your stem cells show signs of transforming into bone cells?”
“Ah… yes, Teacher Shuya.” He Youwei was like a chick pecking at rice: “Teacher, have you studied this?”
“You don’t need to study it. You haven’t learned the third gene law yet. Once you learn this law, you can substitute it into the code to know which gene fragments correspond to functional cells. This is basic content in the process of inducing stem cells to transform into functional cells. Once you are familiar with it, you will know the corresponding functional cells as soon as you see the corresponding gene sequence.”
“I see.” He Youwei was thinking, what kind of foundation is this? Even the experts who specialize in stem cell directed induction research probably don’t know this kind of foundation.
At the same time, she also felt that Jiang Miao and his wife were both geniuses. After she learned a little bit, she realized how powerful their research was.
All I can say is that she knows nothing about cheating.
In the next few days, He Youwei followed Shuya to do research in the laboratory. As she learned more, she became more and more adept at applying those genetic laws.
However, they are still not as good as Jiang Miao and Shu Ya, who have a photographic memory and master all the genetic laws.
But even so, He Youwei felt as if she had opened up her Ren and Du meridians and entered a whole new biological world.
This made her feel like she couldn’t stop, and at the same time, she had firm confidence in treating her systemic lupus erythematosus.
Especially after learning about the two genetic rules of the immune system genes, she realized that it was not difficult to shut down part of the body’s immunity.
During the experiment, under Shuya’s guidance, she fully turned on the immune system of pig stem cells, turning it into an indiscriminate attack mode, and then stimulated several specific gene targets through drugs to gradually shut down the fully turned on immune system until it returned to normal levels.
If Shuya had not forbade her to conduct experiments on herself and asked her to do in vitro cell cultivation and research first, He Youwei might have been eager to try it on herself.
After all, the drugs used on pig stem cells are common ingredients extracted from several natural herbs and animals. Calculated based on the ratio of body weight, they do not reach a toxic dose.
In fact, He Youwei also discovered that this treatment method is not only very accurate, but also uses relatively small doses of drugs.
For example, one of the organic macromolecules extracted from plantain has been tested on animals in other domestic research institutions, and the poisoning dose was 0.032 mg per kilogram of body weight.
However, when used on pig stem cells, the dosage is only 0.0024 mg per kilogram of body weight, which is about one-fourteenth of the toxic dose.
The situation is similar for other drugs used in combination, that is, there is a lot of room for adjustment within the dose range that is close to the toxic dose.
Moreover, during the research process, He Youwei also discovered that the drugs, elements, vitamins, and nutrients that can act on these gene targets are often not single-one-to-one, but multiple ingredients can act on the same target.
This brings another benefit, which is that you can choose an ingredient with relatively fewer side effects, thereby reducing the toxic side effects of the drug on the body.
The reason why other scientific research institutions have not discovered that these ingredients can be used for gene target therapy is mainly because some ingredients have no obvious effect when used alone, but must be used in combination.
This requires in-depth study of Jiang Miao’s genetic law system, as well as understanding of various functional genomes, gene groups, and gene families, before systematic combination therapy can be achieved.
Otherwise, even if you eat a ton of plantain, it will be useless and you may be killed by the toxic side effects.
It was the combination drug regimen on pig stem cells, with dosages within a safe and controllable range, that made He Youwei eager to try. Fortunately, Shuya reminded her that there are differences in the genes of humans and pigs, and what works for pigs may not have the same effect on humans.
at the same time.
In the past few days, Jiang Miao also asked someone to investigate whether there are any pharmaceutical companies suitable for acquisition.
After several days of searching, business secretary Liu Deming knocked on the door with a document.
“Boss, this is a listed company that is currently on the verge of bankruptcy or is not doing well.”
Jiang Miao opened the document and took a quick look at it.
There are two companies in total:
Tongyuan Kang Pharmaceutical, the company submitted an application for listing to the Hong Kong Stock Exchange last year. It currently has no commercialized products. The cumulative losses in 2022, 2023, 2024, and the first three quarters of 2025 added up to approximately 1.47 billion yuan, and its net debt reached 1.271 billion yuan.
Its core product TY-9591 is a third-generation EGFR inhibitor. Although it has shown preliminary superior efficacy in clinical trials, it has been trapped in a red ocean before it was launched on the market and there is also the risk of patent disputes. It was successfully launched in August last year, but is now on the verge of bankruptcy.
Qiongzhou Haiyao, whose main business includes research and development, production and sales of medicines and medical devices, showed in its 2024 financial report that its total operating revenue was 925 million yuan, a year-on-year decrease of 42.36%, and its net profit attributable to shareholders was a loss of 350 million yuan, and its non-net profit was a loss of 220 million yuan.
The company has performed poorly in recent years and faces great operating pressure and financial difficulties. Its R&D investment may be restricted, affecting the progress of its pharmaceutical and medical device R&D projects.
Jiang Miao directly crossed out Qiongzhou Haiyao. This kind of company was too troublesome, and its size was not small, so the acquisition funds were too much.
On the contrary, Tongyuankang Pharmaceutical, which is on the verge of bankruptcy, can be considered for acquisition. If debts are included, it should be possible to acquire it for around 3 billion yuan.
However, after he looked into the details of Tongyuankang Pharmaceutical, he felt that this company would probably be difficult to manage.
Because the founders of this company are three senior practitioners in the pharmaceutical industry. They are either PhDs in the field of pharmaceutical research and development or experts in drug development and clinical trials. Such people will not sell the company easily.
Moreover, the company has a complete industrial chain. It has established R&D centers and production bases in Hucheng, Modu, and Shangdu in Zhongyuan Province, and has drug R&D and production capabilities.
This means that the other party will not let go easily.
Just at this moment, Li Jianming called.
“A Miao, have you found a suitable pharmaceutical company?”
“not yet.”
“I have a friend who wants to sell a pharmaceutical company. He acquired a small pharmaceutical company in Yangcheng a few years ago, but the business turned out to be very bad.”
“Are the documents in order?”
“It is complete. The R&D and production procedures for drugs and medical devices are complete. There are also two factories, one for producing ibuprofen and the other for producing masks and protective clothing.”
“How much did he offer?”
“The factory is located in the suburbs of Conghua District in the northeast of Yangcheng. He wants 200 million yuan for the land and office buildings of the two factories, plus the production line and related certificates and access qualifications.”
“Send me the information on WeChat, and then I’ll send someone to investigate the specific situation.”
“Can.”
After a while, Li Jianming sent the relevant information.
Jiang Miao took a look.
The company is called “Xinlekang Pharmaceutical”.
With the name and shareholder information, for Jiang Miao, it is basically equivalent to information transparency.
He asked business secretary Liu Deming to go out.
Then, through the Internet, quickly dig out all the information about the company and its shareholders.
After reading the relevant information, Jiang Miao has understood the specific situation of this company. It is indeed poorly managed. The major shareholder is not a professional. After acquiring this pharmaceutical company in 2017, he was deceived into developing an anti-aging drug. After investing 500 million yuan, he found out that he was deceived. The person who deceived him has already fled to the Maple Leaf Country with his entire family.
If he hadn’t made a fortune from ibuprofen, masks and protective clothing in the past few years, he would probably be regretting it.
In the past two years, with the decline in market demand, Xinlekang Pharmaceutical has been hit back to its original state. Seeing that the company is struggling, this person has learned his lesson and is ready to sell the company.
However, after the news was released, no one was interested.
In fact, this is normal. After all, such small pharmaceutical companies are looked down upon by large and medium-sized domestic pharmaceutical companies. Small pharmaceutical companies can hardly survive on their own, and other non-professional investors are also deterred from the pharmaceutical industry.
It was not until Jiang Miao said a few days ago that he wanted to acquire a pharmaceutical company that Li Jianming remembered the pharmaceutical company his friend wanted to sell, so he planned to act as a matchmaker and do him a favor.
Jiang Miao took a look. Although Xinlekang Pharmaceutical only had two factories, there was also a pharmaceutical research and development laboratory in the ibuprofen factory. It was previously invested in to develop new drugs. The instruments and equipment inside were worth about 80 million yuan. This was also the most valuable thing of the company besides the office building and the set of certificates and procedures.
As for the other ibuprofen production lines, mask production lines and protective clothing production lines, they are not worth five million in total. After all, these are third-hand equipment.
Even the value of the two industrial plots of land is not that great. The total of 96 acres of land, including the factory buildings, is worth 90 million yuan; the office building is worth about 27 million yuan.
As for laboratory equipment and factory equipment, I guess the other party also knows that these are second-hand goods and it is difficult to bid high enough.
That’s why the total price was 200 million.
The price was not a big deal and was within Jiang Miao’s acceptable range. He then packaged some of the information that could be collected on the surface of the Internet and sent it to his business secretary Liu Deming, asking him to instruct the purchasing department to send someone to inspect the Xinlekang Pharmaceutical Company.
As for the positioning of the pharmaceutical company, Jiang Miao only planned to set up a joint-stock limited company, with himself as the chairman, and then recruit a professional manager as the CEO, plus He Youwei as the chief technology officer.
He doesn’t plan to keep many shares of this company, and some people who need to join can be brought into this company.
However, he, Shuya, and He Youwei will set up a joint-stock company, separate the research and development business of the pharmaceutical company, sell it to this company, and then register all related patents under the name of this company, and then authorize the pharmaceutical company to use them regularly and free of charge, using an annual signing method to license the technology to the pharmaceutical company.
In this way, even if Jiang Miao and He Youwei do not own the majority of the shares of the pharmaceutical company, they can still firmly control the pharmaceutical company.
In order to maximize profits, it is even possible to license technology to multiple domestic pharmaceutical companies.
Jiang Miao himself only plans to focus on the agricultural industry. Perhaps Shuya can develop medicinal fungi in the future, but that is a matter for the future.
Therefore, he has a completely nonchalant attitude towards pharmaceutical companies. After all, if he and his family need drugs, he can secretly synthesize some in his own laboratory.
After the pharmaceutical company is established, Jiang Miao will not hand over too many technologies to the company. After all, many technologies are too sensitive.
For example, by studying genetic rules and using specific drugs to act on corresponding gene targets, he can effectively inhibit the shortening of telomeres, thereby delaying aging to a certain extent, and probably extending lifespan by more than ten years.
If this technology were released now, Jiang Miao would definitely become the target of public criticism.
For example, his brain-boosting diet regimen, if this technology were to become known, it would probably trigger a world war.
Therefore, the technology that can be licensed to pharmaceutical companies for use is most likely similar to drugs used to treat systemic lupus erythematosus, such as drugs for treating specific allergies, infertility, Alzheimer’s disease, hyperlipidemia, hypertension, hyperglycemia, hyperuricemia, and various cancers.
However, extending life and enhancing brain power are absolute taboos.
Before I knew it, it was already the 6th.
Yang Hejun, chairman of Chengyi Group, visited with five employees.
“Brother Yang, hello!”
“Junior brother Jiang Miao, I’m sorry to bother you. This is just a small token of my appreciation.” Yang Hejun handed him a few bags with a smile.
Jiang Miao had no choice but to accept it and take the other person into his temporary office.
Tea has been prepared in the office.
After taking a seat, Jiang Miao poured tea for him and asked with a smile, “Brother, you came here this time. The dock just happened to have collected a few wild groupers today. Let’s try some at noon.”
“Junior brother, you are too polite.” After taking a sip of tea, Yang Hejun shook his head and joked, “Junior brother, your company will probably surpass mine soon. You can’t refuse to admit your age!”
“Haha, it just happened to be a good opportunity.”
“Hey, Junior Brother, you are too modest. Without skills, no matter how many opportunities you have, it will be useless.” Yang Hejun immediately changed the subject: “Junior Brother, this time I came to visit mainly to see if I can cooperate with your company.”
“Brother, please feel free to speak.” Jiang Miao poured some more tea for the other party.
“Then I’ll be frank, Junior Brother Jiang, I want to cooperate with your company to develop feed that can shorten the grass carp breeding cycle. I have learned about your company’s eel feed and Egyptian catfish feed, which can effectively shorten the breeding cycle or increase the growth rate.” Before coming here, Yang Hejun had actually learned about the relevant situation of Hailufeng Company.
Especially when he learned that Jiang Miao graduated from Lion Rock Agricultural University, he quickly asked Lion Rock Agricultural University to help him make the connection.
“Grass carp feed?” Jiang Miao also knew about Chengyi Group’s business. The other party had a 16,000-acre breeding base for breeding grass carp.
Under intensive breeding conditions, grass carp usually takes about 1.5 to 2 years before it can be sold.
Such a long breeding cycle will not only cause a surge in breeding costs, but also increase uncontrollable risks and prolong the capital recovery cycle.
Yang Hejun was also shocked to see that Jiang Miao could shorten the eel breeding cycle from more than a year to seven months.
“Brother, actually our company has reached an agreement with Haida Group. In the future, we will gradually develop customized feed made from Egyptian catfish meal. Of course, this agreement does not have an exclusive clause, so if our company successfully develops a grass carp-related feed formula, we can also authorize it to Chengyi Group for use.”
Hearing this, Yang Hejun was also surprised.
Of course he knew about Haida Group. After all, they were both enterprises in Lingnan Yangcheng, and the two parties had overlapping businesses.
Chengyi Group also produces feed, but their company generally produces and sells it itself, with an annual output of about 40,000 to 60,000 tons.
“In that case, I won’t force it.” Yang Hejun talked about another matter:
“Junior Brother Jiang, I wonder if the technology related to Egyptian catfish meal can be licensed to our company for use?”
Jiang Miao shook his head: “Brother, you might as well purchase directly from Haida Group. Their Egyptian catfish meal will be mass-produced next year. Anyway, your grass carp breeding cycle is relatively long. You can use the feed made from Egyptian catfish meal to feed it for a year, and then use other feeds for the rest of the time. Adding a running water pool can effectively reduce the earthy smell.”
After Jiang Miao’s explanation, Yang Hejun gave up the idea of ​​raising Egyptian fish and planned to purchase from Haida Group when its Egyptian fish meal is produced next year.